Congratulations to Professor Tzyh-Chang Hwang and his research team for their groundbreaking publication in Nature Communications

We are thrilled to share that Professor Tzyh-Chang Hwang’s latest study has been published in Nature Communications. The research team has successfully resolved the cryo-EM structure of CFTR in complex with the CFTR inhibitor 172. This study reveals critical interactions within the CFTR pore and uncovers an allosteric modulation mechanism for the drug, offering new insights into diseases caused by hyper-activated CFTR and paving the way for future therapeutic strategies.
Please join us in congratulating Professor Hwang and his team for their remarkable contributions to the scientific community! 👏

Reference: Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore. Nat Commun. 2024 Aug;15:6668. doi: 10.1038/s41467-024-50641-1.